Atleti centre-back Diego Godin has already spoken of the need to play "with the heart and the legs", but there will also be significant financial factors at play.
The Spanish side will be deploying all their heavy artillery for this one, with Antoine Griezmann and Diego Costa likely to start together in attack.
With the ever-impressive Jan Oblak between the sticks and Atletico's penchant for solidity, 'Los Colchoneros' are considered favourites ahead of the game, despite Marseille's impressive performances this season.
Should they claim the victory, the Madrid-based side will pocket €6.5m, plus TV money, taking their earnings to some €26.6m across the tournament as a whole (Including the €16m for participating in the Champions League Group Stage). Whilst that figure is much lower than it would have been for a successful Champions League campaign, given the cost of their move to the Wanda Metropolitano, every penny counts.
If Atletico fall to defeat, they will take home €3.5m less.