The round's action got off to a pulsating start as Real Madrid went down 4-1 to an impressive Ajax side. Tottenham beat Dortmund 1-0 and progressed 4-0 on aggregate in the day's other game.
Manchester United pulled off a similarly impressive comeback against PSG, winning 3-1 on the night and going through on away goals. Porto triumphed after extra time to defeat Roma in Wednesday's other encounter.
Manchester City routed Schalke 7-0 to book their place in the quarter-finals, while Atletico Madrid went down 3-0 to Juventus, who were inspired by a Cristiano Ronaldo hat-trick.
And then, in the tournament's most recent action, Barcelona saw off a spirited Lyon side while Liverpool pulled off an impressive victory over Bayern Munich.