Wenger will draw the curtain on an illustrious 22-year reign at Arsenal in front of the Huddersfield Town crowds at 16:00 (CET), hoping to sign off his 828th match with a win.
However, for Arsenal, they will also be bidding farewell to defender Per Mertesacker, who will switch from a player to a coach for the 'Gunners'. The defender has barely featured this season but is expected to play some part on Sunday to receive a deserved standing ovation.
All the way up in Manchester, Old Trafford will be the perfect setting for supporters to see Michael Carrick in the famous red shirt for the last time. After almost 700 games, the midfielder is retiring and will stay at the club in a coaching capacity.
For Jose Mourinho, there will be two goodbyes though as his assistant manager, Rui Faria, has decided to step out from the shadows and start a solo career.
In the blue half, Manchester City's Yaya Toure will also play his last game whilst in Wales, Swansea are losing two loyal servants in Angel Rangel and Leon Brittan.
It seems the final day of the Premier League season is one for goodbyes. And with uncertainty over the futures of Wayne Rooney, Antonio Conte and Mohamed Salah, there could be more than we think...