England travel to Seville to face Spain in the UEFA Nations League, as the 2010 World Cup champions aim to put the recent disappointment behind them.
Many had tipped Spain for success, however they fell short of Russia after a frustrating draw and pre-tournament chaos with Lopetegui's dismissal days before the tournament kicked off.
"There's a bitter taste in the mouth from Russia, given we were knocked out of the tournament so early, while knowing that we had a team that could've competed with the best," Ramos, who could earn his 157th cap in his home city of Seville, told 'Sky Sports'.
"That wasn't the case, but now we're into a new era with a new coach. I think our mentality is very positive once again and we have to try to achieve our targets.
"We have to enjoy the Nations League, which is an important competition and it's what lies ahead of us, so we want to start with a good run of results, perform well and win, as we've been doing.
"We have a very important game against England tomorrow, which will be a fantastic clash", he added.
If Spain beat England they will confirm their spot as group winners in their respective Nations League.
"I think they're a very good side," said the Real Madrid defender. "They've been going through a new cycle, with players leaving the national team.
"But they are a team that compete very well, with players that can make things happen and are very dangerous going forward.
"They'll be tough opponents for us, but we'll try to hurt them in the ways that we've been working on for some time."