Southampton: The hosts look thin up top for this one as both Shane Long and Charlie Austin look set to loses their races to be fit with toe and hamstring issues respectively. However, Danny Ings is expected to be fit after needing painkilling injections to play before the international break due to a blister problem.
Brighton: Playmaker Pascal Gross faces a late fitness test but the club are hopeful he has sufficiently shaken off his ankle knock. Winger Jose Izquierdo and new boy Florin Andone are both back in training and could play some part.
Southampton boss Mark Hughes on Brighton:
"They've got a lot of guys that have grasped the opportunity to play in the Premier League and are enjoying the day-in and day-out challenge the Premier League brings.
"Along with that, they've still got a guy up top [Glenn Murray] who is a little bit older than some of the rest in the group and still has an impact for them. You have to be respectful of the talent they have."
Brighton boss Chris Hughton:
"Southampton are on the back of a very good win in their last game [at Crystal Palace] and are a team I'm sure will be playing with a lot of confidence.
"What we can't do is underestimate the qualities they have got. They have got a very good squad and a very good team.
"We will have to play at the levels that we have done in the last three games to give ourselves a chance."
Did you know?
Southampton have only lost once in the last eight meetings between the two sides (W3, D4, L1).
Southampton have only won one of their last 13 home league games (W1, D6, L6).
Saints have failed to win in their last 10 Monday Premier League games (W0, D3, L7).
Brighton have so far failed to claim an away league point this season.
Glenn Murray has scored four goals in five league starts for Brighton against Southampton.
Form:
Possible lineups:
Southampton: McCarthy; Soares, Vestergaard, Hoedt, Bertrand; Elyounoussi, Lemina, Romeu, Hojbjerg, Redmond; Ings.
Brighton: Ryan; Montoya, Dunk, Duffy, Bong; Knockaert, Stephens, Propper, March; Gross; Murray.