The Swiss international, born to Kosovan-Albanian parents, was left behind for the trip to Belgrade, with his manager keen to avoid any distractions in the build up to the important group stage clash.
Shaqiri angered Serbian people during the World Cup; he wore boots with the Kosovo flagged stitched into the side, and celebrated scoring against them by using the Albanian 'double-eagle' signal.
However, in a very dull and disappointing display, Jurgen Klopp may have rued his own decision to leave Shaqiri behind, as the 'Reds' fell to a poor defeat away in Serbia.
Yet the Liverpool fans need not be worried, as Shaqiri returned to brilliant effect, scoring the second goal in a 2-0 victory over Fulham in the Premier League on Sunday.
After the game, the Swiss was keen to insist his acceptance of his manager's decision to leave him out of the clash with Red Star Belgrade, stating: "There is a very hot atmosphere there and so it was better to stay at home and just concentrate on football. I was fresh, I stayed here and trained with some other players but it doesn't change a lot. "
Shaqiri continued: "In the end it is the coach's decision who is playing and against who. If he decides to play you from the beginning, nice and good, but also if you are on the bench, try to come in and make an impact. Only 11 players can play and we have a big squad (so) everybody has to accept the decisions of the coach and until now it's going very good and we are in a good way."
Jurgen Klopp has somewhat adapted his tactics this season in order to accommodate the influential Shaqiri . The Liverpool boss has often opted to use a 4-2-3-1 formation, as opposed to the 4-3-3 system that worked so well last season.
Nonetheless, Shaqiri is well aware of how to adapt to playing with such talents like Salah, Mané and Firmino, as many will remember his stint with German giants Bayern Munich some three seasons ago.
Although he knows the quality that his current crop of teammates possess, Shaqiri was reluctant to compare them to his former Bundesliga teammates just yet. He added: "I knew already how good these very talented players (were). We have a very good team, a young team also, so our process is going very well and I'm just proud to be part of this team."
With the commencement of the international break, Shaqiri will have to bide his time in trying to impress manager Jurgen Klopp, as Liverpool's next game does not arrive until November 24th, when they travel to London to play Watford.