1. Arsenal V Tottenham, London - 12:30PM GTM.
Ah, the North London derby, not a bad way to get back into the swing of Premier League football. This fixture has produced some memorable moments in recent years, with goals from David Bentley and Danny Rose immediately springing to mind, but who will claim the bragging rights this time? Arsenal's home form has been their strength this season, whilst Spurs have looked a better side away from home. Arsenal have a point to prove after finishing below Spurs last season for the first time during Arsene Wenger's time in charge, whilst Mauricio Pochettino's side will be looking to live up to their title of the new Kings of North London. Join us tomorrow for live coverage of the game.
2. Roma V Lazio, Rome - 2:00PM GMT.
Not one for the feint hearted this one. Both sides are looking to launch a genuine title challenge this season, with the two teams currently occupying fourth and fifth positions in Serie A. With just a point between them, this promises to be the fiestiest Rome derby in recent memory. Lazio go into the game as the form side having won their last six league games in a row, whilst in Ciro Immobile, they also have Serie A's top striker so far this campaign. However, Roma are not to be underestimated, with their thrashing of Chelsea in the Champions League at the Stadio Olimpico a demonstration of their abilities.
3. Istanbul Basaksehir V Galatasaray, Istanbul - 4:30PM GMT
Okay, this one might not look quite a big as the others, but it could still end up having a major impact on the title race. Galatasaray currently top the Turkish league, three points ahead of Basaksehir in second. For is certainly on the side of the hosts going into the game, with Istanbul having not lost in their last 27 home games. The hosts have also won the last three meetings between the two sides, with Emmanuel Adebayor scoring a hat-trick in a 4-0 victory the last meeting of the teams.
4. Atletico Madrid V Real Madrid, Madrid - 8:45PM GMT
Two sides having endured frustrating starts to the season will face off at the Wanda Metropolitano on Saturday night. With both sides already eight point behind leaders Barcelona, defeat for either could end their title hopes before they ever really began. It's fair to say that the two sides are familiar to each other, having played out 12 derbies since the start of 2015. Real have only won three of those in 90 minutes. With both Cristiano Ronaldo and Antoine Griezmann having failed to find their scoring boots so far this season, the game provides them both with the perfect opportunity to give themselves an enormous confidence boost and get the fans back on side. Join us tomorrow for live coverage of the game.