Jose Luis Morales and Roger has brutally punished two mistakes from Raphael Varane to give the visitors a shock lead, with the Frenchman first misjudging a long ball forward and then handling to give the hosts a penalty.
'Los Blancos' went into the game having failed to find the net in almost seven hours of football, but that run appeared to be over when Asensio, the scorer of their last goal back on September 22, headed home after Sergio Ramos's header from a corner had come back off the bar.
The Real Madrid players wheeled away in celebration, only for the man in the middle to initiate a discussion with the linesman on the far side.
The assistant appeared to indicate that Asensio had been in an offside position when Casemiro made the initial contact, a suspicion that was confirmed by VAR, with the goal being chalked off, much to Madrid's frustration.