The Dutch side went into the game at the San Siro with nothing to play for other than pride, but they succeeded in breaking Inter hearts as they held out for a 1-1 draw.
The Italians knew that they would advance if they bettered Tottenham's result against Barcelona at the Camp Nou and with the English side only managing a draw, a win on home turf would have seen Inter through.
However, things got off to the worst possible start just 13 minutes in, with Hirving 'Chucky' Lozano heading PSV ahead after Kwadwo Asamoah had been caught in possession at the back.
Inter were left with little option but to throw caution to the win and pile bodies forward and eventually found a levelled with 73 minutes on the clock as talismanic striker Mauro Icardi nodded home Mateo Politano's cross.
With Barcelona leading in the other game at the group that briefly left Inter looking like they would be the ones advancing to the last 16, only for Lucas Moura's late leveller to leave them resigned to a place in the Europa League.
Inter miss out on away goals in their head-to-head record with Spurs, with both sides claiming eight points from their six group games.
December 11, 2018