"It's forbidden for anyone who is a PSG supporter to enter the Stade Velodrome", or drive or park their cars in the streets around the ground, a police statement declared.
Sunday's clash is considered high risk with trouble flaring at numerous meetings between Marseille and PSG fans over the years.
"Relations between Marseille and PSG fans have been marked by animosity for many years," the police noted.
This is the second time in a week that PSG have been deprived of their supporters after their fans were banned from Sunday's trip to Saint Etienne.
PSG won that fixture 2-0 to stretch their lead at the top of ligue 1 to 24 points.