Unai Emery's men will turn out against a record-breaking Manchester City side which will further strengthen their side in this summer's transfer window.
However, it's not just Arsenal who face a difficult start to the campaign. In fact, Wolves will face tough opposition in their first few mathces back in England's top flight, with matches against Leicester, Man City, Burnley and Man Utd in their first six matches.
The newly-promoted teams generally face stiff opposition on their returns to Premier League football, with Cardiff City facing a consecutive run of Arsenal, Man City, Tottenham and Liverpool in August and September.
Fulham also face a visit to the Ethihad Stadium in September, as well as August matches versus Tottenham and Burnley.
While the teams coming up from the Championship all face difficult starts, any point picked up in these initial games could give vital confidence to their progress as the season goes on.