Mourinho announced yesterday that Morgan Schneiderlin and Memphis Depay will not be considerer, as their future at the club is unresolved.
Wayne Rooney is likely to return to the starting line-up , while Sergio Romero could replace De Gea in the goal.
Here are the probable line-ups:
Manchester United: Romero, Darmian, Smalling, Blind, Shaw, Fosu-Mensah, Pogba, Rooney, Young, Rashfod, Mkhitaryan.