The French midfielder will line up alongside Nemanja Matic and Ander Herrera in midfield, behind an attack full of pace.
Jose Mourinho opted to field Alexis Sanchez, Anthony Martial and Jesse Lingard in his front three, in what will surely be a fluid unit as there is no recognised striker among the three.
Juventus will have Cristiano Ronaldo playing the central role, with Paulo Dybala and Juan Cuadrado providing the width. Meanwhile, Sami Khedira returns to the midfield in the place of Blaise Matuidi.
Giorgio Chiellini returns to partner Leonardo Bonucci in defence as Juventus look to confirm their place in the knockout stages of the champions league.
Man United XI: De Gea, Shaw, Lindelof, Smalling, Young, Matic, Hererra, Pogba, Martial, Lingard, Sanchez
Juventus XI: Szczesny, Sandro, Bonucci, Chiellini, De Sciglio, Pjanic, Khedira, Bentancur, Dybala, Cuadrado, Ronaldo