Philippe Coutinho opened the scoring for 'Los Cules' in the 11th minute after prodding home from close-range.
And Barcelona's lead would be doubled just five minutes later in a very similar move.
The La Liga champions worked the ball around to Lucas Digne on the left who squared it across to the Brazilian midfielder to tap into an empty net.
The goal would have lifted Ernesto Valverde's side as they attempt to finish the league campaign undefeated.