Frank Lampard's side needed one point from their last game of the season to be sure of featuring in the Champions League for a second successive season.
First half goals from Mason Mount and Olivier Giroud at Stamford Bridge ensured there was never any doubt they would achieve that target.
Despite some stumbles since the coronavirus hiatus, Chelsea held onto the top four berth that had been theirs for most of the season.
The Blues had not ended a round of fixtures outside the top four since October 6.
Wolves finish seventh and will only qualify for the Europa League if Arsenal win the FA Cup.