Manchester United:
The Red Devils will be determined to bounce back from their shock defeat to rock-bottom West Brom two weeks ago. With a two goal cushion and two games in hand on third-place Liverpool, Jose Mourinho's side could cement second place with a win over Arsenal.
The only name on United's short injury list is that of substitute goalkeeper Sergio Romero who is recovering from a knee injury.
Arsenal:
Arsenal's inconsistent form lately and difficulty keeping clean sheets will make fans nervous about this clash. That said, with Alexandre Lacazette and Pierre-Emerick Aubameyang firing on all cylinders, anything is possible.
Long-term injured Santi Cazorla (achilles) and Mohamed Elneny (ankle) are unlikely to feature for the Gunners.
United boss Jose Mourinho:
Reflecting on his rivalry with Arsene Wenger, the Portuguese manager said: "We had big matches, big fights, so thank you so much for that."
Arsenal boss Arsene Wenger:
"We've had some great battles in 22 years. If I get a good reception, I'll take it."
Flashback:
Let's rewind time to the 'Battle of Old Trafford' in 2003 when Ruud Van Nistelrooy blew his chance to beat the Invincibles before chaos descended on the tie and a mass brawl ensued.
Did you know?
Of all the clubs in England's top four divisions, Arsenal are the only side to have lost every one of their away league matches this calendar year.
Possible line-ups:
Manchester United: De Gea; Valencia, Smalling, Bailly, Young; Mata, Matic, Pogba; Lingard, Sanchez, Lukaku.
Arsenal: Cech; Monreal, Chambers, Kolasinac, Bellerin; Xhaka, Willock, Mkhitaryan; Welbeck, Lacazette, Aubameyang.