The Ligue 1 side topped Group C, which included Anderlecht, Mainz and FK Qabala, and are currently eighth in the French top tier.
Elsewhere Villarreal will go up against Italian giants Roma, in which promises to be one of the ties of the competition.
The Serie A side finished top of Group E, while their Spanish opponents were runners up in a group containing Osmanlispor, FC Zurich and Steau Bucherest.
Tottenham will face Belgian side Gent, who squeezed into this round of the competition with a late goal in their last outing against Konyaspor.
Mauricio Pochettino's side dropped into the Europa League having finished third out of four in their Champions League group, consisting of Monaco, Bayer Leverkusen and CSKA Moscow.