Loftus-Cheek made a brief cameo against Tunisia and impressed as England found a late goal to give them all three points.
Raheem Sterling will also keep his place, as will Jesse Lingard despite missing a number of chances during the first half against Tunisia.
This means that Marcus Rashford will once again have to make do with a place on the bench after starring in the warm up games for the tournament.
England would confirm qualification for the last 16 with a win and even a point would see them eliminate the north African side.
Probable England team:
Pickford, Trippier, Walker, Stones, Maguire, Young, Loftus-Cheek, Henderson, Lingard, Sterling, Kane.