Liverpool: Naby Keita could be involved despite being carried off in the Champions Legaue defeat to Napoli in midweek after suffering a back spasm. However, Jurgen Klopp is expected to keep faith with James Milner, Jordan Henderson and Giorginio Wijnaldum in the middle of the park. Adam Lallana is closing in on a return to fitness, but Alex Oxlade-Chamberlain remains sidelined long term.
Man City: Kevin De Bruyne and Benjamin Mendy both returned to training this week and could be involved in some capacity, though the Frenchman is the more likely of the two to start. Ilkay Gundogan faces a race against time to shake off a hamstring injury to play, whilst Fabian Delph remains out.
Liverpool boss Jurgen Klopp:
"I don't think it makes sense in this moment to think about the title. Manchester City is always tough, even when we won 3-0 in the Champions League. In the 4-3 [Liverpool win] they were really good. They never gave up even at 4-1 down.
"We have to be spot on, at our best to keep them away from our goal and create chances in front of our goal. It will be hard work, no problem with that, everybody knows it."
Man City boss Pep Guardiola:
"Liverpool will beat a lot of teams, not just Man City. Liverpool is one of the true greatest teams in England. We try to be close to them in terms of many, many things.
"[Jurgen Klopp] has all the qualities that everybody knows about Liverpool. At the end, it's the teams and the clubs that win the game. I don't play against the manager, we play against Liverpool. He is an excellent manager, I have a lot of respect for the way he plays, his proactive teams."
Form:
Did you know?
Liverpool are unbeaten in 17 home games against Manchester City in all competitions (W12, D5, L0).
City last beat Liverpool at Anfield back in May 2003, claiming a 2-1 Premier League win.
Liverpool are on a 24-match unbeaten run at home in the Premier League.
The Reds' last defeat at home to a top-six club came against Manchester United in January 2016.
Liverpool are on a run of eight consecutive home clean sheets, one away from equaling the club record.
Mo Salah has scored in 14 of his last 16 starts at Anfield.
Manchester City's only loss in their last 25 Premier League away games came in January's 4-3 reverse at Anfield (W20, D4, L1).
Pep Guardiola has lost seven times against teams managed by Jurgen Klopp, more than any other manager.
Possible lineups:
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Milner, Henderson, Wijnaldum; Salah, Firmino, Mane.
Man City: Ederson: Walker, Kompany, Laporte, Mendy; Fernandinho, B.Silva, D.Silva; Sterling, Aguero, Sane.