After both sides won their respective European clashes in midweek, Liverpool and Everton head into the game in a spot of good form. Everton are yet to lose under new manager Sam Allardyce, who has urged his players to stick to their plan and not let the enormity of the occasion intimidate them.
"The whole occasion is a great test for the players," Allardyce said. "It is one they need to rise to and no matter how well Liverpool are playing at the moment it is a derby and anything can happen. All I can ask the players is to play their best game."
"We don't want to let the occasion overawe us... We know we probably won't have as much possession as Liverpool do but we need to ensure we maximise it when we do and use it in the right manner. Then when we get a chance, we need to be very clinical. Hopefully that can give us a good performance and at the end of that a result."
Liverpool's 7-0 win over Spartak Moscow extended their unbeaten run to nine games in all competitions but Jurgen Klopp remains cautious: "The challenge for all of us in the stadium is that we don't expect that we play football like we did in the last 20 minutes against Moscow," Jurgen Klopp said. "That was confident, that was flying, all that stuff - we have to start from the ground, from the basics again."
"We have to be ready for hard challenges. But, from our side for sure, it should not be only hard. That's all that we know about a game like this, and then we can win the game."
Phil Jagielka is set to return to the Everton squad for Sunday's Merseyside derby, but he may have to may have to settle for a spot on the bench alongside Michael Keane. James McCarthy and Yannick Bolasie are back in training but will not be available at Anfield.
Liverpool left-back Alberto Moreno could be sidelined for up to six weeks with an ankle injury and James Milner is likely to fill the vacancy. Jordan Henderson is set to start in midfield after sitting out in midweek.
Recent form:
Possible lineups:
Liverpool: Mignolet, Gomez, Lovren, Klavan, Milner, Mane, Wijnaldum, Can, Coutinho, Salah, Firmino
Everton: Pickford, Kenny, Holgate, Williams, Martina, Gueye, Lennon, Davies, Rooney, Sigurdsson, Calvert-Lewin