Lewandowski, who finds out Thursday whether he has been voted FIFA's player of the year having been shortlisted alongside Cristiano Ronaldo and Lionel Messi, has scored 18 goals in 17 games for Bayern this season in all competitions.
"I haven't thought about it (the awards), I was just focused on this game - I'm pretty relaxed about it, let's see what happens," he told Sky after his two goals.
Leverkusen, who host Bayern in Saturday's top-of-the-table clash, remain first in the table - a point ahead of Munich - after a 4-0 romp away to Cologne in the Rhineland derby.
Wolfsburg took a shock lead within five minutes at the Allianz Arena when Leroy Sane's error on the edge of the area led to Maximilian Philipp smashing home the loose ball.
Wolfsburg's Dutch striker Wout Weghorst then had a goal ruled offside on 17 minutes.
However, Lewandowski reached the 250-goal milestone when he headed Bayern's equaliser just before the break.
He became only the third to achieve the feat alongside Bayern legend Gerd Mueller and Schalke striker Klaus Fischer.
Lewandowski then fired the winner into the bottom corner of the net on 50 minutes.
He has now claimed 23 goals in 20 league matches against Wolfsburg.
Wolfsburg suffered their first league defeat this season as Bayern got back to winning ways after drawing their two previous league games.
In Cologne, Leverkusen remain the league's only unbeaten team after racing into a 2-0 lead on ten minutes thanks to goals by Mitchell Weiser and Moussa Diaby.
Czech striker Patrik Schick added Leverkusen's third early in the second half when he buried Diaby's cross before former Cologne player Florian Wirtz grabbed the visitor's fourth.
Things remain tight at the top of the table as third-placed RB Leipzig stayed level on 28 points with Bayern with a 1-0 win at Hoffenheim thanks to Yussuf Poulsen's second-half winner.