Leicester City, who are behind second-placed United in the Premier League only on goal difference, were knocked out after sliding to a 2-0 loss at home to Czech champions Slavia Prague.
Lukas Provod fired Slavia in front just after half-time following a goalless draw in the first leg, and Senegalese teenager Abdallah Sima ensured the visitors extended their run in the competition. "We didn't create enough over two legs. We didn't defend with any intensity. We gave away two disappointing goals. The better team won," said Leicester coach Brendan Rodgers.
AC Milan squeezed past Red Star Belgrade on away goals after a 1-1 draw in a clash of former European champions at the San Siro. Franck Kessie's early penalty was enough to book Milan's place in the last 16 despite El Fardou Ben Nabouhane equalising as the tie finished 3-3 over the two legs.
Egyptian forward Ahmed Hassan's 88th-minute strike in Eindhoven sent Olympiakos through at the expense of PSV 5-4 on aggregate, while Roma and Young Boys brushed aside Braga and Bayer Leverkusen respectively.
Dinamo Zagreb and Dynamo Kiev complete the line-up for the last 16, with Tottenham Hotspur also in the mix after destroying Wolfsberg of Austria by an aggregate score of 8-1 on Wednesday.
Standout matches today