José Sánchez Martínez will take charge of Sevilla-Real Madrid with César Soto Grado in charge for Barcelona's trip to Cádiz.
Javier Alberola Rojas will referee Granada-SD Huesca and Alejandro Hernández Hernández will be the leading man when Betis travel to Osasuna.
The full list is below:
Athletic Club-Celta
Referee: Jorge Figueroa Vázquez (C. Andaluz)
VAR: Carlos Del Cerro Grande (C. Madrileño)
Levante-Getafe
Referee: David Medié Jiménez (C. Catalán)
VAR: Isidro Díaz De Mera Escuderos (C. Castellano-Manchego)
Sevilla-Real Madrid
Referee: José Sánchez Martínez (C. Murciano)
VAR: Ricardo De Burgos Bengoechea (C. Vasco)
Atlético de Madrid-Valladolid
Referee: Pablo González Fuertes (C. Asturiano)
VAR: Jesús Gil Manzano (C. Extremeño)
Cádiz-Barcelona
Referee: César Soto Grado (C. Riojano)
VAR: Ignacio Iglesias Villanueva (C. Gallego)
Granada-SD Huesca
Referee: Javier Alberola Rojas (C. Castellano-Manchego)
VAR: Adrián Cordero Vega (C. Cántabro)
Osasuna-Betis
Referee: Alejandro Hernández Hernández (C. Las Palmas)
VAR: Antonio Mateu Lahoz (C. Valenciano)
Villarreal-Elche
Referee: Santiago Jaime Latre (C. Aragonés)
VAR: José Luis González González (C. Castellano-Leonés)
Alavés-Real Sociedad
Referee: José Luis Munuera Montero (C. Andaluz)
VAR: Jua Martínez Munuera (C. Valenciano)
Eibar-Valencia
VAR: Valentín Pizarro Gomez, (C. Madrileño)