United found themselves two goals down inside 20 minutes on the south coast and whilst they fought back to claim a point thanks to goals from Ander Herrera and Romelu Lukaku, the result saw their winless streak in the Premier League extend to three matches.
The result, combined with leaders Manchester City's victory over Bournemouth, means that United are now 16 points off the pace of their bitter rivals and embarrasingly sit closer to the relegation zone than the summit of the division.
Saturday's draw ensured a disappointing week ended on a bum note for United, who also drew with Crystal Palace at Old Trafford last weekend and scraped to the narrowest of victories over Young Boys in the Champions League on Tuesday.
Speaking on 'Sunday Supplement', Crafton insisted that enough was enough and that Mourinho's two and a half years in charge should be brought to an end.
"It's the week that confirms that Manchester United need to change their manager," Crafton insisted.
"The theory was Mourinho's pragmatism maybe gets them over the line over the course of the season. It's now becoming clear if you can't beat Crystal Palace at home, Southampton away, it's as generous as fixtures you can get - Young Boys at home.
"Watching Manchester United now is an ordeal. You're watching Mourinho on the touchline more for him than the players.
"The players aren't offering anything generally. They have to make a change now really. I don't think the fans are enjoying watching their team. Yesterday the first 20 minutes was as bad as anything I've seen from Manchester United since Sir Alex Ferguson retired.
"It's a very dispiriting place at the moment. They were so far adrift of Manchester City a few weeks ago. Before that they seemed to have had a bit of a renaissance but since then it is back to where it was before."