Zinedine Zidane's side travel to the south of Spain to take on Malaga in the weekend's late kick-off. Stars Cristiano Ronaldo, Gareth Bale and Luka Modric have been rested for the match, with the club keeping one eye on their Champions League semi-final showdown with Bayern Munich on April 25.
However, it gives other players the chance the shine and one of those will be Isco, who has found memories of 'La Rosaleda' after spending two seasons there earlier on in his career (2011-12 and 2012-13).
It will be the tenth time that the Spanish midfielder has returned to his former club, although in all those encounters, including the ones at the Bernabeu, Isco has failed to score.
In the matches at Madrid's famous stadium, the 25-year-old has seen four victories and one draw, but has not found the back of the net nor provided an assist in all five matches.
The record is slightly better at 'La Rosaleda', in which during 'Los Blancos' 2-0 victory on May 21, 2017, Isco made the key pass to Cristiano Ronaldo which resulted in a goal in the 2nd minute.
With seven goals and eight assists to his name this year, the Spain international will hope to be the protagonist against his former club to cement his place in his national team's squad for the World Cup in the summer.