Manchester City manager Pep Guardiola hit out at the "crazy" decision from the Brazilian Football Confederation (CBF) to invoke a FIFA suspension for Ederson and Gabriel Jesus.
City duo Ederson and Jesus were – among the majority of other South American players in the Premier League – not released by their clubs for the recent round of World Cup qualifiers on the continent.
Premier League clubs unanimously agreed last month they would refuse to release players called up by nations that are on the British government's travel red list amid the coronavirus pandemic.
All of South America is on this list, and players would have had to quarantine in a hotel for 10 days upon their arrival back in the United Kingdom, leaving them unavailable for at least two league games and next week's European fixtures.
Spurs trio Davinson Sanchez, Giovani Lo Celso and Cristian Romero nevertheless joined up with Colombia and Argentina respectively, while Aston Villa's Emiliano Martinez and Emiliano Buendia also travelled, though the Argentine contingent agreed to return early.
However, Martinez, Lo Celso and Romero were at the centre of incredible scenes in Sao Paulo last weekend when Brazilian health authority officials stormed onto the pitch to detain the trio, as Brazil's travel rules demand individuals to isolate if they have been in the UK within 14 days of their arrival in the country.
Explaining his frustration and confusion, Guardiola pointed to this fact after Brazil invoked a FIFA ruling to prevent clubs from fielding the players they did not release.
Ahead of Saturday's trip to Leicester City, Guardiola told a news conference on Friday: "Right now it still isn't clear, hopefully they can play, we will wait and see tomorrow if there is some good news. The club didn't inform me of anything. So we are going to wait and see if they can play or not.
"I don't understand the situation for the fact that I don't know what we can do. It's an honour for us that our players go and play for the countries where they are born. It's no problem at all.
PEP (on international break) We have three weeks to prepare but not before that and then we have an international break and then three weeks and after an international break.
"It's difficult to justify for me that the Argentina players who play in the Premier League, they go to Brazil and they were not allowed to play, and the Brazilian players who should have travelled to play this game would have been completely the same.
"So if they travelled there, they wouldn't have been able to play because of the quarantine there. If they do it so they [fly to Brazil] but cannot play in Brazil and after when they came back they could not play here for 10 days. And if they don't fly, then after they are suspended for five days because they were here. So it makes no sense.
"Argentina travelled with some players, the police were on the pitch, and they could not play the game because they didn't follow the protocol.
"So it would have happened with the Brazil players. And after the federation from Brazil asked FIFA to ban these players that cannot travel to play with them, but they could not play there, and now they could not play here? It's crazy."
With Zack Steffen isolating in the United States having tested positive for COVID-19, Guardiola will likely have to call on veteran goalkeeper Scott Carson to make just his second City appearance if Ederson is rendered unavailable – the former England international's only previous outing being in a 4-3 win over Newcastle United back in May, his first top-flight appearance in a decade.
Ferran Torres scored a hat-trick in that match and, after netting twice against Arsenal last time out, has now been involved in six goals in his last six league appearances.
Jesus, playing on the right of City's front three, has also made a strong start to the season and would be a miss for Guardiola's team. Indeed, the forward has only scored more times against Everton (eight) in the Premier League than he has in meetings with Leicester (five).
Guardiola was at least able to offer positive news on the fitness of Phil Foden and Kevin De Bruyne.
"Yesterday Phil made the first training session, and Kevin was training alone and then with the players still here," he said. "They're feeling much better."
Standout matches today