Germany's youthful squad cruised through the group stages despite wobbly defensive displays, including mistakes from Arsenal's Mustafi and goalkeepers Leno and Ter Stegen.
The Barca stopper looks to play today having taken Leno's place between the sticks, while goal machine Timo Werner will lead the line.
Mexico will have to deal with the injuries of Diego Reyes and Carlos Salcedo, as well as 136-cap Andres Guardado, who is out due to suspension.
Germany: Ter Stegen, Kimmich, Ginter, Mustafi, Hector, Goretzka, Rudi, Emre Can, Süle, Draxler, Werner
Mexico: Ochoa, Layún, Araujo, Moreno, Alanís, Herrera, Aquino, Jonathan, Fabián, Vela, R Jiménez