The Three Lions travel to the Estadio Benito Villamarin, the home of Real Betis, on Monday in the knowledge that La Roja can secure top spot in the group with a game to spare.
Speaking in the build-up to the game, Ramos said that England's status as the country that gave football to the world makes victory over them all the sweeter.
"I've played many matches against English clubs and the national team – and I always notice a difference in those games," he told the 'Daily Mirror'.
"When you play against the inventors of football, it adds more importance to the result and you can see that demonstrated by the levels on the pitch.
"To play and to win against England is big news around the world and footballers are always grateful for that."
England striker Harry Kane recently denied reports that he is suffering from fatigue, insisting that he wants to play on Monday night and as well as predicting a bright future for England's young squad, also highlighted Kane as the danger man.
"I am expecting a beautiful, but intense, match," he continued. "Harry Kane is a very complicated player to stop. That is clear and at Wembley he caused our defenders to work very hard.
"England have called up young players who are dangerous and quick and I can see the future looks good for this squad."