If England are able to overcome the plucky Welsh side on Friday, they will secure their place at France 2019.
A draw would keep them in control of their own destiny, while a loss would mean that they would have to qualify via the play-off stage.
England manager Phil Neville believes that Friday's fixture is the perfect opportunity for England to show everyone what they're made of.
"When I took the job the remit was to win the World Cup and I wasn't scared of that expectation," Neville told 'Sky Sports'.
"The goal from me has not changed and I want to set the bar really high. I want to go to a World Cup and I want to win a World Cup."
"But to do that, you're going to have to play well and that's why on Friday, to fulfil our dreams, we're going to have to play to our maximum."
Neville was appointed in January this year, and since then has overseen two wins and a draw, which came against Wales.
Welsh fans and players have been describing Friday's match as the biggest in their history as a team, but Neville doesn't want his side to get carried away:
"Everyone keeps telling me it's a massive game," Neville said.
"I just see it as an important game really because you can build games up bigger than they actually are."
"I want my players to be relaxed going in there on Friday. We've worked well all week. My team are fully fit. We're looking forward to the challenge ahead."