Eder recalled as holders Portugal target Euro 2020 finals
The 31-year-old returns as part of a 25-man squad named by coach Fernando Santos as Portugal attempt to lock down a place at Euro 2020 over the final two qualifying rounds.
They host Lithuania, the bottom side in Group B, in the Algarve on November 14 before making the trip to Luxembourg three days later.
Eder's last appearance for his country came almost a year ago but he is included after a strong start to the season in Russia, where he has scored four times in nine league games.
Portugal are without Andre Gomes who suffered a horrific leg injury playing for Everton at the weekend, while teenage star Joao Felix and Goncalo Guedes are also sidelined.
Uncapped forward Diogo Jota is one of four Wolves players selected by the UEFA Nations League winners.
Portugal are second in their group but just one point ahead of Serbia following a 2-1 loss to leaders Ukraine in Kiev last month.
Goalkeepers: Rui Patricio (Wolves/ENG), Beto (Goztepe/TUR), Jose Sa (Olympiakos/GRE)
Defenders: Ricardo Pereira (Leicester/ENG), Nelson Semedo (Barcelona/ESP) Jose Fonte (Lille/FRA), Pepe (FC Porto), Ruben Dias (Benfica), Ruben Semedo (Olympiakos/GRE), Raphael Guerreiro (Borussia Dortmund/GER), Mario Rui (Napoli/ITA)
Midfielders: Danilo Pereira (FC Porto), Ruben Neves (Wolves/ENG), Bruno Fernandes (Sporting Lisbon), Bernardo Silva (Manchester City/ENG), Joao Mario (Lokomotiv Moscow/RUS), Joao Moutinho (Wolves/ENG), Pizzi (Benfica)
Forwards: Bruma (PSV Eindhoven/NED), Daniel Podence (Olympiakos/GRE), Diogo Jota (Wolves/ENG), Andre Silva (Eintracht Frankfurt/GER), Cristiano Ronaldo (Juventus/ITA), Goncalo Paciencia (Eintracht Frankfurt/GER), Eder (Lokomotiv Moscow/RUS)