The Belgian playmaker had to kick the ball out of play so he could receive treatment, before being replaced by Fernandinho before half-time.
De Bruyne played a crucial role as City won the league last season, but has struggled with persistent injury issues this year.
He missed eight league games at the start of the season with a torn knee ligament, and missed six more shortly after with another ligament injury.
He has also had a thigh problem this season, which saw him miss City's clash with Watford on March 9th.
The champions went into the break leading 1-0 thanks to Phil Foden's close range header.