The 27-year-old injured his right knee in training after City's season opener against Arsenal, and originally looked set for a lengthy three-month spell on the sidelines.
However, De Bruyne has seemingly returned quicker than expected, after just six weeks and may be in line to feature against the German outfit this week.
Guardiola's side will need to bring three points back from Germany, following a disappointing opener at the Etihad against Lyon.
The Belgian international could also be in contention to start against Liverpool on Sunday in a top-of-the-table clash at Anfield, where City would be glad to see him return, as the 'Sky Blues' have won won at the ground since 2003.