With the focus shifting back to club football after yet another international break, clubs are understandably worried about whether their players will be coming back in peak physical condition following long flights and games in all corners of the world.
However, the stats show that City tend not to be affected by post-international break fatigue, with Pep Guardiola's side having won their last five games to come immediately after the pause (this season and last season).
The reigning Premier League champions welcome Burnley to the Etihad on Saturday as they look to continue that fine record, having thumped Liverpool 5-0 and Stoke 7-2 following the first two international breaks of last season.
Arsenal also have a strong record, winning four of their last five, though there will be slightly more concern from Chelsea and Tottenham, who have each managed just nine points from the 15 on offer following international duty.
That leaves them a point behind West Ham, Watford. Burnley and Liverpool, who have the bonus of facing Huddersfield in Saturday's late kick-off, with no team boasting a worse post-international break record than the 'Terriers', who have neither claimed a point nor scored a goal after the last five international breaks.
Manchester United go into their heavyweight clash with Chelsea on Saturday unbeaten in their last five games after internationals, an interesting sub-plot in a tricky game for United and former 'Blues' boss Jose Mourinho.