In an intriguing opening tie in the round of 16 draw for the Champions League, Pep Gaurdiola's side will head to Germany once more, as they have been drawn against Bundesliga outfit Schalke 04.
The two sides have only faced each other a total of three times throughout history, with the English side holding a slight advantage, having won twice to the German club's sole victory.
The most recent meeting of the two sides was back in 2008, when manager Mark Hughes guided his City side past Schalke 04 in the UEFA Cup.
Perhaps the most significant individual player for the tie will be Leroy Sané; the German is due to return to his boyhood club, with whom he rose through the ranks before becoming a world star, and earning his move to Manchester in 2016.
Another face returning to a former employer is 25 year old defender Matija Nastasic. The Serbian is set to return to the Etihad stadium, where he spent three years as a player, winning the Premier League title in 2013-14.
The English side will be the favourites for the tie, as they are favourites for the entire competition, but they should not underestimate the Germans.
Seven time Bundesliga winners, and Champions League semifinalists in 2011, 'Die Knappen' has an esteemed reputation for being a constant conveyor belt of upcoming talents.
Nevertheless, with Manchester City due to play the first leg away and host the return tie in England, Guardiola's side will fancy themselves to battle through to the quarter-finals of the competition.