Burnley: The hosts will be without Icelandic winger Johann Berg Gudmundsson after he picked up a hamstring injury. Youngster Dwight McNeil filled is as the 'Clarets' were knocked out of the Europa League by Olympiakos in midweek, but Sean Dyche could opt to play full-back Charlie Taylor in front of Stephen Ward as part of a more cautious approach.
Manchester United: Jose Mourinho will have to shuffle his defence once again, with Phil Jones having succumbed to a hamstring injury of his own during the defeat to Tottenham on Monday. Marcos Rojo has returned to training, but this game will come just to early for him.
Burnley boss Sean Dyche on his side's European adventure:
"I think we've learned a lot on and off the pitch, about travelling, organisation, all the things that come with it.
"I think you saw a team who wanted it to carry on by the way, which is important considering how all of you have been saying how nobody wants it.
"But that is a mentality more than anything here - we want to win every game that we play."
Manchester United boss Jose Mourinho:
"I am the manager of one of the greatest clubs in the world but I'm also one of the greatest managers in the world.
"I have won eight titles. I'm the only manager to win in Italy, Spain and England. Not small titles, proper titles, and my second last season was one of my greatest achievements in football."
Did you know?
Burnley have only won one of their last 17 top-flight encounters with United, with that victory coming in their first Premier League meeting back in August 2009. (W1, D8, L8).
Manchester United have kep nine clean sheets in their last 10 trips to Turf Moor.
Sean Dyche has lost all six meetings with Jose Mourinho as a manager.
Burnley only claimed one point at home against the top six last season, drawing 1-1 with Manchester City at Turf Moor in February.
The 'Clarets' are on an eight-game winless streak. (W0, D3, L5).
Alexis Sanchez has scored four goals in five Premier League appearances against Burnley.
Form:
Possible lineups:
Burnley: Hart; Lowton, Tarkowski, Mee, Ward; Lennon, Cork, Hendrick, Westwood, Taylor; Wood.
Manchester United: De Gea; Valencia, Smalling, Bailly, Shaw; Matic, Pogba, Fred; Sanchez, Lingard; Lukaku.