Borussia Dortmund:
Peter Bosz has confirmed Pierre-Emerick Aubameyang will return following his suspension for missing a team training session.
He will, however, be without winger Marco Reus, midfielder Sebastian Rode, and defenders Erik Durm and Lukasz Piszczek.
Alexander Isak and Sokratis Papastathopoulos are also doubts.
Tottenham:
The visitors can secure top spot in Group H if they match Real Madrid's result against Apoel Nicosia on Tuesday evening.
Danny Rose is likely to start this match after being left out against Arsenal on the weekend, but Harry Kane and Dele Alli are doubts after they were taken off in the second half in the north London derby.
Son Heung-min and Fernando Llorente could come in to replace the England duo.
Victor Wanyama and Toby Alderweireld remain sidelined with knee and hamstring injuries respectively, while Erik Lamela continues to recover from a problem with his hips.
Recent form:
Possible lineups:
Borussia Dortmund: Burki, Toljan, Zagadou, Bartra, Guerreiro, Castro, Dahoud, Sahin, Yarmolenko, Pulisic, Aubameyang
Tottenham: Lloris, Sanchez, Dier, Vertonghen, Aurier, Winks, Dembele, Rose, Eriksen, Son, Llorente