Barcelona will face their first Clasico since 2007 without Lionel Messi after the Catalans' captain sustained a fractured arm against Sevilla.
Messi had already set one goal up and scored another in Saturday's top-of-the-table clash at Camp Nou before he fell awkwardly.
The five-time Ballon d'Or winner was in obvious pain, although Barca's medical team dressed his right arm and it initially appeared as though he may attempt to play on.
Messi was withdrawn after a long delay, however, and Barca confirmed in a statement after their 4-2 win that tests showed a fracture in his right arm.
It means next Sunday's match between Barca and Real Madrid will be the first Clasico without either Messi or Ronaldo for 11 years.
Using Opta numbers, we assess Messi's record in one of the world's most important football fixtures.