There was a possibility that the 'Blaugrana' could play Manchester United or Liverpool, so they will be relieved to have been drawn against Lyon, although the French side can cause problems.
They have already shocked Manchester City in the group stage, and came close to twice beating Pep Guardiola's English champions.
And, with Barcelona having shown defensive frailties that were not a part of last season's almost-unbeaten campaign, the likes of Memphis Depay and Nabil Fekir will fancy their chances of an upset.
Ernesto Valverde's side currently sit top of a volatile LaLiga table, but they have been far from convincing. More often than not they have had to rely on the brilliance of Lionel Messi.
The Argentine is in fine form, already into double figures for both goals and assists this season, but if Lyon can find a way to slow him down it could be anyone's game.