Panucci scored the winner for Italy against Scotland in a 2-1 win to end Alex McLeish's side's dreams of reaching Euro 2008, and is after another victory, this time with Albania.
Speaking ahead of the tie, Panucci said: "We will give them the utmost of respect but we will try and win the game."
The Scots fell to 4-0 defeat against Belgium on Friday, whilst Albania won their Nations League opener against Israel.
"The Scots will be suffering after the defeat and will be low on confidence", added Panucci.
"We know Scotland have good quality and are difficult to play against.
"We know our strengths and weakness but we come here to win the game.
"This is a completely different game [from Israel]. We will have different tactics but we won't be playing the long ball. If we make the same mistakes as we did against Israel, Scotland will punish us dearly.
"I don't think there is a favourite for the group but clearly if we win, it gives us a big advantage. We need to be ready to win.