Although it won't be decisive between the two teams themselves... this derby could have a major impact on the remainder of this year's Premier League campaign.
The battle for the title is one of the tightest in recent years and City are need to win Wednesday's derby. If not, they leave Liverpool with the trophy on a silver platter.
Anything other than a Citizen triumph will be celebrated in Liverpool, as the Reds currently hold the lead with 88 points and one match more than Manchester City. Only a City victory would cause a switch-up at the top.
If City get the three points, it will be their responsibility to claim the title over the remaining three matches, but if they do not win, it will be Liverpool who do. The war is open, but Manchester United also have a lot to say.
The team led by Solskjaer is, with 64 points, sixth in the table and also have something to play for since, in case of victory, they would be level on points with Chelsea, who are currently occupying the final Champions League qualifying position.
So, there are three teams involved in the derby. Liverpool will undoubtedly support Manchester United and Manchester City have the opportunity to stick it to both their neighbour and rival as well as the other title contender.