In 37 official games, the Argentine star has scored 25 goals. He has come out on the winning side 18 times - drawing eight and losing 12. Madrid are one of his favourite victimes.
There is one statistic in particular which reveals the impact that Messi has had, not only on Madrid but on their race for trophies. With the Argentinian in play, Real Madrid have won 18 titles - Barcelona have 32.
The discrepancy is even greater when it comes to league titles. Real Madrid had 29 league titles before Messi burst onto the scene, Barcelona had 16. The Catalans have increased their tally by nine in that time whereas Real have only won four.
Although Real Madrid have come to dominate in Europe in recent years, Messi has also won four Champions League titles in his career (2006, 2009, 2011 and 2015) while Real Madrid have three (2014, 2016 and 2017). 'Los Blancos' can equal the tally in Kiev later this month.
Messi comes into this subdued Clasico in great form. Barcelona are already cup and league champions. Only the debate over the guard of honour has created any drama over what is usually the most anticipated game of club football in the world.
But Messi is also after the Golden Boot. There are still challenges for Messi after he was decisive in the first game of the season. He scored once, from the spot, and played a part in the other two as Barca won 3-0. Challenges for Real Madrid as well then.