A beautiful commemoration to the Manchester victims preceded the final, ending in chants of 'Manchester, Manchester' coming from both sets of fans, and the Red Devils came out to a strong start as they took the Dutch side by surprise.
With Rashford successfully closed down by centre-back Sanchez, Pogba began to find space as he looked for that magical moment to prove himself decisive for Mourinho's team.
However, it was Ajax who forced Romero into action first, with Traore looking to pop the ball inside the near post. The Dutch side were very unfortunate to go behind in the 17th minute, when Pogba had a go from outside the penalty area. The Frenchman's low shot took a wicked deflection off Sanchez to wrong-foot Onana, who could only watch and see the ball find the back of the net.
Ajax's youthful side looked taken aback following the goal, and captain Valencia looked to take advantage with a bursting run down the right flank ending in a strike which was parried away by Onana.
The Dutch team successfully claimed control of the ball, but they were not managing to break down the solid defensive display set up by United's back four.
Mourinho's men managed to shake off the pressure, and they put the game out of reach for Ajax after a perfect start to the second half.
The corner kick was swung into the box and Smalling nodded the ball down into the six-yard box. Mkhitaryan was there to swivel and turn the ball acrobatically into the back of the net, awarding the Red Devils a relieving two-goal cushion.
The side managed by Jose Mourinho shut up shop after doubling their lead, with Ajax left needing a quick response to get back into the clash.
The Dutch team, however, were too slow and predictable in their build-up play, and it was all too easy for Manchester United to shut them down. Ziyech created some danger as he blazed his effort over the bar, but United looked more dangerous on the break with chances coming for Fellaini or Lingard, who burst down the middle toward the end, before Sanchez powered him off the ball.
Mourinho's team did not need a third goal as Ibrahimovic joined his teammates in the dugout in anticipation of the celebration to come. Neres had one final chance to pull one back when he got in behind the defence and lobbed the ball over Romero, but the ball was cleared and the referee whistled for the end of the game.
A solid yet unflashy performace for the Red Devils to overcome a young and brave Ajax side. United qualify for the Champions League while also lifting their third trophy of the season.