PSG left Toulouse with a narrow 1-0 win in Ligue 1 on Saturday courtesy of Zlatan Ibrahimovic's second-half strike, but Dominique Arribage's side were buoyed by their display against the runaway league leaders.
"It won't be the same story tomorrow (Tuesday)," Arribage said at Monday's press conference.
"It's up to us to rise to the occasion. We have plenty of hope because they know we could hang with them and beat them.
"We have to go to the Parc des Princes full of ambition. We're setting ourselves up for a good performance, we're not going there to concede five (goals) but that could happen."
Laurent Blanc will be without injured stars Thiago Silva, Marquinhos, Javier Pastore and Marco Verratti, but Argentine winger Angel Di Maria is set to return after sitting out Saturday's game with a sore foot.
Blanc may also rest Marco Verratti, who is struggling with a groin problem, amid a congested fixture list which includes another meeting with Toulouse on January 27 in the semi-finals of the League Cup.
PSG are set to embark on a run of seven matches in little over three weeks before hosting Chelsea in the first leg of their Champions League last-16 tie on February 16, and they would play another game before facing the Premier League champions should they advance on Tuesday.
"We're playing matches every three days, but it's the same for a lot of teams," said Blanc.
"The players are ready for it and we will rotate because we have to keep them fresh. (But) you can't become obsessed by just the Champions League. There is more to it than that.
"We would like to have everyone fully fit to take on Chelsea but to do that, to make sure players remain match fit, they have to play."
There are three other all-Ligue 1 ties, with record 10-time winners Marseille hosting Montpellier, 2014 champions Guingamp visiting Gazelec Ajaccio and Angers at home to 2013 winners Bordeaux, as a record 17 top-flight sides remain in the competition at this stage.
Lyon will look to recover from Sunday's 1-0 defeat to bitter rivals Saint-Etienne when they travel to third-tier Chambly on Wednesday, while Monaco go to second-tier Evian.
Fixtures
Tuesday (all times GMT)
Gazelec Ajaccio v Guingamp, Rennes v Bourg-en-Bresse (1700), Angers v Bordeaux (1730), Bastia v Sochaux, Sarre Union v Niort (1800), Paris Saint-Germain v Toulouse (2000)
Wednesday
Trelissac v Lille, Evian TG v Monaco, Mantes v Nantes (1700), Chambly v Lyon, Concarneau v Troyes (1730), Boulogne v Lorient (1800), Marseille v Montpellier (2000)
Thursday
Saint-Etienne v Ajaccio (2000)