The Real Madrid captain enjoyed something of a busy day, guiding his side to victory but not before giving them a scare.
With just minutes to go before kick-off at the Coliseum Alfonso Perez, Ramos was found vomiting in the dressing room.
Zidane immediately decided that the former Sevilla man should be withdrawn from the starting line-up but the defender refused.
The club's medical staff sprang into action, administering the 31-year-old with an intravenous drip and the player was able to complete 90 minutes as Real ran out 2-1 winners thanks to goals from Karim Benzema and Cristiano Ronaldo.
Whatever the mystery illness was, Real will be hoping that Ramos is over it and that it doesn't spread to the rest of their squad with a Champions League clash against Tottenham on the horizon.