Nine-time winners PSG are bidding to repeat last year's domestic treble and beat Lyon 2-1 at the Parc des Princes last week to reach the semi-finals of the League Cup.
Record 10-time champions Marseille face fourth-tier outfit Trelissac, who stunned Lille on penalties in the previous round.
Saint-Etienne, 2-1 winners over Ajaccio on Thursday, head to Ligue 1 relegation favourites Troyes, while Bordeaux host Nantes in the other two top-flight ties.
Monaco are away to second-tier Sochaux, with teams from the fourth division awaiting both Lorient and Gazelec Ajaccio.
Fifth-tier Granville and Sarreguemines are the lowest-ranked sides left in the competition, with the winner of Saturday's last-32 tie set to face Ligue 2 outfit Bourg-en-Bresse
The matches will be played on February 9-10.
Saint Malo v Gazelec Ajaccio
Sarre Union v Lorient
Paris Saint-Germain v Lyon
Granville or Sarreguemines v Bourg-en-Bresse
Troyes v Saint-Etienne
Trelissac v Marseille
Sochaux v Monaco
Bordeaux v Nantes