The Italians have a good record against Premeira Liga opposition winning their last three games on Portuguese soil.
Belenenses are playing in their first group stages and are undefeated in Europe this season, claiming a point in a goalless draw at Lech Poznan in Poland.
The Italians are riding high after a Nikola Kalinic hat-trick inspired them to a 4-1 win over Inter Milan at the weekend to sit top of Serie A for the first time since 1999.
By contrast their rivals sit just three points above the relegation zone in Portugal.