The Red Devils opened their season in style, with stand-out displays from Nemanja Matic and Romelu Lukaku, the striker scoring a double on his Premier League debut for the club.
Swansea are currently in mourning after losing key man Gylfi Sigurdsson, the Iceland international making a £45m switch to Everton. They will miss the midfielder, who scored the equaliser when the two sides last met at Old Trafford last season.
The Welsh club only recorded four shots on goal in their opening draw against Southampton, but they make up for their lack of flair up front with solid defensive performances. The side managed by Paul Clement are unbeaten in their last six Premier League matches (W4, D2).
The Swans will also have to cope with Fernando Llorente's injury, as well as Leon Britton's back injury. Mourinho will have to do without injured trio Luke Shaw, Ashley Young and Marcos Rojo. Summer signings Roque Mesa and Victor Lindelof could make their respective league debuts.
Possible lineups for Swansea City v Manchester United:
Swansea: Fabianski; Olsson, Fernandez, Mawson, Naughton; Fer, Britton, Carroll; Ayew, Routledge, Abraham.
Man Utd: De Gea; Blind, Jones, Bailly, Valencia; Matic, Herrera, Pogba; Martial, Mkhitaryan, Lukaku.