Key players such as Benjamin Mendy or Paul Pogba will have to sit out through injury or suspension, but here are the best players at their manager's disposal.
Goalkeeper: David De Gea (United)
Right centre-back: Kyle Walker (City)
Centre-back: Eric Bailly (United)
Left centre-back: Nicolas Otamendi (City)
Left winger: Leroy Sane (City)
Holding midfielder: Nemanja Matic (United)
Midfielder: David Silva (City)
Midfielder: Kevin de Bruyne (City)
Right winger: Raheem Sterling (City)
Forward: Sergio Aguero (City)
Forward: Romelu Lukaku (United)
Bench: Ederson (City), Antonio Valencia (United), Marcos Rojo (United), Fernandinho (City), Henrikh Mhkitaryan (United), Bernardo Silva (City), Jesse Lingard (United), Marcus Rashford (United), Anthony Martial (United), Gabriel Jesus (City), Zlatan Ibrahimovic (United)