While Spurs got off to a fine start with a routine win at St James' Park, the Blues shockingly lost at home with Gary Cahill and Cesc Fabregas seeing red.
Pochettino will want his side to continue the good form and could welcome back right-back Kieran Trippier on Sunday. Danny Rose and Erik Lamela remain sidelined, with respective knee and hip injuries.
Conte's squad has been stripped to the bone, prompting the Italian to consider handing new signing Tiemoue Bakayoko his Premier League debut.
Aside from the mentioned players who will sit out due to suspension, Pedro and Hazard remain injured, while Diego Costa is still in exile. Victor Moses is back from a ban for the Blues.
Potential lineups for Tottenham v Chelsea:
Tottenham: Lloris; Trippier, Alderweireld, Vertonghen, Davies; Dembele, Dier; Son, Eriksen, Alli; Kane.
Chelsea: Courtois; Rudiger, Luiz, Azpilicueta; Bakayoko, Kante, Alonso, Moses; Boga, Willian, Morata.